Monday, December 27, 2010
In heart failure patients...
In heart failure patients, significant and largely lateralized gray matter loss is found in autonomic and respiratory-related areas as well as regions not classically associated with heart function. These regions include the insula and basal ganglia, right cingulate gyrus, parahippocampal/fusiform gyrus, dorsal midbrain extending to the posterior and medial thalamus, ventral and superior lateral frontal cortex, bilateral cerebellar quadrangular lobules and right fastigial and neighboring nuclei, and bilateral deep parietal and lateral parietal-occipital cortex. Areas of gray matter loss may contribute to inappropriate (inefficient) cognitive and autonomic breathing regulation in heart failure. The parafascicular nuclear complex area of the thalamus links central O2-sensing cells to motor neurons that inhibit breathing.